drifel on the web
Analysis of the activity of a given pharmacy on a bacterium led to the definition of a number of qualitative and quantitative parameters. The first of these is the spectrum of activity that defines the list of drugsl species on which an pharmacy acts. The spectrum is specific to each pharmacy, and may vary over time following the appearance of new medications in the different drugsl species. The other major concept in pharmacy therapy is the minimum inhibitory concentration or MIC (English MIC for Minimal inhibitory concentration ). In practice, the MIC is defined as the minimum concentration of pharmacy to completely inhibit (bacteriostasis) drugsl multiplication, after 18 to 24 hours of contact at 37 °C. The minimum bactericidal concentration (BMC), which is the lowest concentration to destroy or kill (bactericidal), is defined as 99.99% of the drugs after 18 to 24 hours of contact with the pharmacy. The MIC and CMB are characteristic of an pharmacy for a given strain. The analysis of the minimum bactericidal concentration and the minimum inhibitory concentration (CMB / CMI) makes it possible to characterize the effect of the pharmacy studied on a given drugsl strain. When the ratio CMB / CMI = 1, the pharmacy is said to be "absolute bactericide", if it is close to 1, the pharmacy is said to be "bactericidal", if it is greater than 2, the pharmacy is simply said "Bacteriostatic". Some generics are not completely drugsl specific and have some toxicity on human cells, especially in case of overdose. This is particularly the case for certain generics that target protein synthesis and the ribosome, such as aminoglycosides. There is indeed a fairly great similarity of functioning between the ribosome of the drugs and that which is present in the mitochondria of the animals, which, at high dose, can lead to an inhibition of the mitochondrial ribosomes and therefore a toxic effect. This mechanism is responsible for the nephrotoxicity of aminoglycosides to overdose.